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Disease Fact Sheet Series:

Reye syndrome

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What is Reye syndrome?
Reye syndrome (RS) is a rare disorder that damages many parts of the body, especially the brain and the liver. Reye syndrome is a two-phase illness because it is almost always associated with a previous viral infection, such as influenza, a common cold, or chickenpox.

Who gets Reye syndrome?
Although it can occur at any age, RS is primarily a children’s disease and most often affects children between the ages of 3-12 years old. 

What is the cause of Reye syndrome?
The cause of RS remains a mystery, but studies have found a link with the use of aspirin during a viral illness. Researchers believe that in some cases it is caused by an abnormal response to aspirin or related products taken during a viral illness.

Is Reye syndrome contagious?
Reye syndrome is not contagious and does not spread from person-to-person.

How is Reye syndrome diagnosed?
The doctor may suspect a child has Reye syndrome based on the symptoms and a history of very recent viral illness. Blood tests, including tests of liver function, may be done. Other tests often are necessary to confirm the diagnosis, including a biopsy of the liver (a small piece of the liver is removed and examined) and a lumbar puncture (spinal tap) to examine spinal fluid.

What is the treatment for RS?
While there is no cure for RS, the symptoms may be treated. A physician may prescribe drugs to control the swelling in the brain, and intravenous fluids to restore normal blood chemistry.

How can RS be prevented?
Although a clear link between aspirin and Reye syndrome has not yet been proven, experts agree that to prevent Reye syndrome, the safest approach is NEVER to give aspirin or aspirin-containing medicines to children. Aspirin containing products may include words like acetylsalicylate, acetylsalicylic acid, salicylic acid and salicylate on the label. Non-aspirin medicines, such as acetaminophen (Tylenol) or ibuprofen, should be used instead.

 When a child is taking aspirin, steps must be taken to minimize the risk of acquiring a viral illness (such as influenza and chickenpox vaccinations).

For more information, contact your
Local Public Health Department

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Last Revised: June 21, 2011