Substance Use: Harm Reduction

Improving outcomes for people who use drugs in Wisconsin

There is an overdose emergency in the United States with more than 100,000 people dying due to an overdose each year. Fentanyl and other adulterants have led to rising overdose rates. Most overdose deaths involve opioids, but deaths involving other types of substances are increasing.

In Wisconsin, overdose deaths have more than doubled in the last 10 years, with Black and Indigenous communities being most impacted. Every life lost to an overdose is preventable.

Providing comfort by clasping hands

Harm reduction is an evidence-based public health approach to prevent overdoses and the spread of infectious diseases, like HIV and hepatitis C. Harm reduction focuses on empowering people to make safer choices to prevent negative health outcomes. People practice harm reduction every day to keep themselves safe. Wearing seatbelts and helmets, driving the speed limit, and exercising are everyday examples of harm reduction.

Harm reduction does not enable drug use. It is an evidence-based practice that saves lives. Harm reduction does not minimize or dismiss the very real risks of drug use. Harm reduction also does not condone, endorse, or encourage drug use or high-risk behaviors.

A set of key principles guide harm reduction approaches.

Benefits of harm reduction programs

Harm reduction programs keep communities safe by providing life-saving resources and education to prevent overdose and the spread of infectious diseases. Harm reduction programs often distribute naloxone, a medicine that reverses overdoses, and safer use supplies to keep people who use drugs alive.

People accessing harm reduction programs receive referrals to mental health services, substance use disorder treatment, and medical care. In fact, people who access harm reduction programs are five times more likely to enter treatment for substance use disorder. Harm reduction programs also help prevent the spread of infectious diseases by offering testing and treatment services. Harm reduction programs often work with law enforcement to provide them with tools to safely respond to calls involving substance use.

What do harm reduction programs look like?

Harm reduction programs make drug use less risky, connect people to resources, and improve health outcomes. Harm reduction programs include a range of services:

Additional resources

Learn more about keeping communities healthy through harm reduction: Harm Reduction: Keeping Communities Healthy, P-03512 (PDF)

Trainings

Safety First: Comprehensive, Harm-Reduction Based, Drug Intervention Curriculum for high school students

Glossary

 
Last revised September 24, 2025