Per- and Polyfluoroalkyl Substances (PFAS)

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a group of man-made chemicals that have been used since the 1950s. Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) are the most widely produced and studied of these chemicals.

Although some of these substances have been phased out of production, such as those through the PFOA stewardship program, they may still be found in everyday consumer products, such as some grease-resistant paper, nonstick cookware, stain resistant fabrics, cleaning products, and other personal care products like shampoo and nail polish.

PFAS include PFOA and PFOS among many other substances

PFAS are a family of man-made chemicals that contain carbon, fluorine, and other elements. The Centers for Disease Control and Prevention (CDC) Agency for Toxic Substance and Disease Registry (ATSDR) has a PFAS family tree that shows how PFAS contain various polyfluoroalkyls and perfluoroalkyls.

There are many abbreviations used to describe PFAS. The table below helps to clarify the most common PFAS abbreviations and pronunciations.

Abbreviation Pronunciation Chemical Name
PFAS p-fas (like fast without the ‘t’) Per- and polyfluoroalkyl substances
PFOS p-fos (like foster) Perfluorooctane sulfonic acid
PFOA (aka C8) p-foe-uh Perfluorooctanoic acid

The acronym PFC has been used to describe perfluorinated compounds in the past. This acronym is no longer used to describe perfluoroalkyl and polyfluoroalkyl substances because it is used to describe perfluorocarbons, which are an entirely different family of chemicals.



These substances have been used in non-stick cookware, water-repellent clothing, stain resistant fabrics and carpets, some cosmetics, some firefighting foams, and products that resist grease, water, and oil.

Over half of our contact with PFAS are estimated to come from food. The main ways people come into contact with PFAS are:

  • Eating food that was packaged in material that contains PFAS.
  • Eating fish caught from water contaminated by PFAS (PFOS, in particular).
  • Drinking contaminated water.
  • Accidentally swallowing contaminated soil or dust.

People may also come into contact with PFAS by using some consumer products, such as non-stick cookware, stain resistant carpeting, and water repellant clothing.

It’s not practical to completely reduce our exposure to these chemicals as they are so common and present in our environment, but we can take simple actions to limit our contact with them. Drink safe water, follow fish consumption advice, and rinse off after touching water that contains PFAS. Even though recent federal efforts to remove PFAS have reduced the likelihood of exposure, some products may still contain them. If you have questions or concerns about products you use in your home, contact the Consumer Product Safety Commission at (800) 638-2772.


Health Effects

Humans and animals react differently to PFAS, and not all effects observed in animals may occur in humans. It's therefore important for you to know:

  • Scientists have ways to estimate how the exposure and effects in animals compare to what they would be in humans.
  • What scientists learn from this process helps them decide how to protect people from harm caused by chemical exposure.

Scientists are still learning about the health effects that various PFAS can have on the body. The more widely used substances, like PFOS, PFOA, perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA), have been studied more than other PFAS.

A large number of studies in people have examined possible relationships between levels of PFAS in blood and harmful health effects in people. However, most of these studies analyzed only a small number of chemicals, and not all PFAS have the same health effects. This research suggests that high levels of certain PFAS may:

  • Increase cholesterol levels.
  • Decrease how well the body responds to vaccines.
  • Increase the risk of thyroid disease.
  • Decrease fertility in women.
  • Increase the risk of serious conditions like high blood pressure or pre-eclampsia in pregnant women.
  • Lower infant birth weights; however, the decrease in birth weight is small and may not affect the infant’s health.

One way to learn about whether PFAS will harm people is to conduct studies in lab animals. Most of these studies have tested amounts of PFOA and PFOS that are higher than levels found in the environment. These animal studies have found that PFOA and PFOS can cause damage to the liver and the immune system, birth defects, delayed development, and newborn deaths in lab animals.

Currently, several federal agencies are in the process of evaluating human health risks of PFAS. For instance, the CDC Agency for Toxic Substances and Disease Registry (ATSDR) recently released a draft review summarizing many of the studies on the toxicity of 14 different PFAS compounds. the Environmental Protection Agency (EPA) is taking several actions to address PFAS, including drafting risk assessments for some PFAS as well.

Most people in the U.S. have PFAS in their blood, similar to the low levels observed in blood for other industrial compound classes like flame retardants and plasticizers. While you can do a blood test to determine the amount of PFAS in your body, there is not enough research to determine the level at which we would expect to see health problems. ATSDR has more information on blood testing.


Wisconsin has sent DNR recommended groundwater standards of 20 parts per trillion (ppt) for PFOA and PFOS individually and combined. We are working on additional recommendations for other PFAS. The EPA does not have drinking water standards for any PFAS, but does have a health advisory level of 70 ppt for combined levels of PFOA and PFOS. Both the EPA health advisory level and the recommended DHS groundwater standard are set at a level to protect people, including sensitive populations like people who are pregnant and babies, from health effects associated with PFOA and PFOS exposures. The groundwater standard recommended by DHS is based on more recent scientific findings.

We are reviewing other states' and federal agencies' guidelines for PFAS in air, soil, water, fish, and wildlife.


The Wisconsin Department of Natural Resources (DNR) has information on current sites in Wisconsin that have PFAS contamination. DNR has fish consumption advisories for areas of the Mississippi River. In other parts of Wisconsin, you should follow the fish advisories for PCBs and mercury as they continue to be the primary concern for Wisconsinites.

ATSDR has additional information on how PFAS impacts your health:

EPA also has information on PFAS.

Last Revised: July 14, 2020

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