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MIS-C: Reporting and Surveillance

MIS-C is a category II reportable condition in Wisconsin. Wisconsin providers should report suspected cases of MIS-C to the Wisconsin Department of Health Services through the Wisconsin Electronic Disease Surveillance System (WEDSS), or by calling the Communicable Diseases Epidemiology Section at (608) 267-9003.


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MIS-C can be difficult to diagnose as it requires a clinical examination and multiple laboratory tests. The syndrome may include:

  • A child presenting with persistent fever, inflammation, and evidence of single or multi-organ dysfunction. This may include children meeting full or partial criteria for Kawasaki disease.
  • Exclusion of any other microbial cause and infections associated with myocarditis.

Early recognition and prompt referral to an in-patient specialist and critical care are essential. Providers should elicit any recent history of illness with COVID-19 and known close contact with individuals who are known to have COVID-19. Testing the patient for current infection (PCR) or past exposure (IGG antibodies) is recommended.

The full MIS-C case definition has been published by the Centers for Disease Control and Prevention (CDC).


When someone is diagnosed with MIS-C, they must be hospitalized in order to get proper medical care and some may have to be admitted to intensive care units. Health care providers should provide disease-specific treatments as appropriate. The American Academy of Pediatrics has published clinical guidance on MIS-C.

Questions about MIS-C? Contact us!
Phone: 608-267-9003 | Fax: 608-261-4976

Last revised July 19, 2023