Multi-System Inflammatory Syndrome in Children (MIS-C)

Multisystem inflammatory syndrome in children (MIS-C) is a rare, but serious condition where parts of the body can become inflamed. This could include inflammation of the heart, lungs, kidneys, brain, skin, eyes, or gastrointestinal organs or clotting disorders of the blood. Most cases of MIS-C are in children between the ages of one and 14 years, but can occur in those from less than one year old to 20 years old. Most cases have also previously tested positive for SARS-CoV-2, the virus that causes COVID-19.

Nationwide, more than 60 percent of reported MIS-C cases have occurred in children who are Hispanic or Latino or Non-Hispanic Black. In Wisconsin, more than 50 percent of MIS-C cases occur in racial and ethnic groups, despite communities of color representing less than 20 percent of the state population. Systemic barriers and social factors including access to quality health care, housing, transportation, and job opportunities, often referred to as systemic racism, has exacerbated the disparate impacts of COVID-19 experienced by Black, Brown, Indigenous, and other communities of color in Wisconsin, including disparities in MIS-C cases. Learn more about the unequal and unjust impact of COVID-19.

The Wisconsin Department of Health Services continues to monitor the situation as we look for this uncommon, yet serious condition in children. Multisystem inflammatory syndrome is one of the ways that COVID-19 continues to affect our communities and is another example of why we must all do our part to stop the spread.

General information on MIS-C, including information
on signs and symptoms, treatment, and resources.

Wisconsin-specific and national MIS-C case counts.


Information for local health departments, health care providers, or those looking for information on reporting, surveillance, or diagnosis of MIS-C.

Information to prevent COVID-19 infection.

Questions about MIS-C? Contact us!
Phone: 608-267-9003 | Fax: 608-261-4976

Last Revised: April 7, 2021