COVID-19: Vaccinator Guidance for Moderna Vaccine

Updates  

  • July 27, 2021:
    • 10-dose vials of Moderna COVID-19 vaccines can no longer be ordered after July 28, 2021. Starting July 29, only 14-dose vials of Moderna COVID-19 vaccine will be available to order in WIR.
    • Contact information has changed for vaccine shipment issues and questions.
Overview

Moderna and Johnson & Johnson COVID-19 vaccines are not authorized for and cannot be administered to anyone under 18 years old, under any circumstances. Currently, Pfizer’s COVID-19 vaccine is the only vaccine with emergency use authorization for individuals 16 years and older.

Moderna filed for emergency use authorization from the FDA to use its COVID-19 vaccine in adolescents ages 12 to 17. See Moderna's press release on the topic. We will share more information as it becomes available.

Moderna, Pfizer, and Johnson & Johnson COVID-19 vaccine products are not interchangeable. The same COVID-19 product must be administered for both doses of the mRNA COVID-19 vaccine series. The Advisory Committee on Immunization Practices (ACIP) does not state a product preference. A person may receive any recommended COVID-19 vaccine series.

 

Moderna’s COVID-19 vaccine is:

 Contraindications

Do not administer the Moderna COVID-19 vaccine to individuals with a known history of a severe allergic reaction (for example, anaphylaxis) to any component of the Moderna COVID-19 vaccine. The list of ingredients is available in the clinical considerations.

 
DHS Guidance and Updates

 Updated doses per vial

10-dose vials of Moderna COVID-19 vaccines can no longer be ordered after July 28, 2021. Starting July 29, only 14-dose vials of Moderna COVID-19 vaccine will be available to order in WIR.

 Guidance for transporting vaccine to an off-site clinic

The Moderna COVID-19 vaccine should be stored and transported in the frozen state at -50°C to -15°C (-58°F to 5°F). If transport at frozen temperatures is not feasible, transportation of one or more thawed vials for up to 12 hours at 2°C to 8°C is permissible with precautions to minimize shaking and vibration.

If the vaccine is being transported at refrigerated temperatures, the total time for transport is 12 hours (cumulative). For example, if the vaccine is transported one hour to a clinic and one hour back to the primary storage unit, the returned vials have used two out of the 12 hour timeframe. These vials can be transported for 10 more hours. The beyond-use date labels for this vaccine have been updated to help providers keep track of transport times. In addition, care should be taken to ensure thawed vaccine does not refreeze.

This information is also included in the latest update of the CDC’s:

Providers must report all temperature excursions (any out-of-range temperatures) to the Wisconsin COVID-19 Vaccine Program within 24 hours at dhscovidvaccinator@wi.gov.

 Advance email notification for COVID-19 vaccine shipments from distributor, McKesson

Vaccine shipments to providers will be preceded by two emails from McKesson. Both of these emails will be sent from cdcnotifications@mckesson.com and will be sent to the provider (facility) level email address that is transmitted with the order in VTrckS. This includes the following emails:

  1. An order acknowledgment email that is sent once the order has been received into the McKesson system.
  2. An advance shipment email that is sent once the order has shipped from the McKesson depot and contains the carrier tracking details.

Please note depending on when orders are placed and McKesson’s shipping timeline, you may receive the vaccine before receiving the shipping email.

If you have questions, please contact McKesson Specialty Customer Care at (833) 343-2703 Monday-Friday, 7 a.m.-7 p.m. CST or covidvaccinesupport@mckesson.com.

 Pulling "extra" doses from one Moderna vial

In some cases, providers may be able to obtain a 15th dose from a Moderna vaccine vial, and this may be used if it is truly a full dose. Whether a 15th dose is obtainable depends, in part, on the type of syringes and needles used to withdraw doses from the vials. Because the vaccine does not contain preservative, it is critical to note that if the amount of vaccine remaining in the vial cannot provide a full dose, discard the vial and content. Do not pool excess vaccine from multiple vials to create one dose.

Please be sure to adjust WIR inventory as needed, based on these instances. Inventory can be adjusted as follows:

  1. Review and address any outstanding transfers and current inventory in WIR. It is important to make sure there are no outstanding transfers of vaccine and all inventory is accounted for prior to making adjustments.
  2. Under manage inventory, select “show inventory.”
  3. Select the applicable COVID site in the site dropdown to review the correct vaccine inventory.
  4. Select the correct trade name and lot number by clicking the checkbox next to the applicable vaccine.
  5. Click “modify quantity” in the upper right.
  6. Modify the total doses in inventory, using “receipt of inventory” as the reason for the adjustment.
  7. Click save.

Detailed instructions with screenshots can be found within Chapter 11 of the WIR User Manual (available on the WIR website after you log on).

Note: An unextracted 15th dose from the larger volume Moderna vial does not result in reportable waste.

Ancillary kits have been expanded to support the administration of 140 doses of vaccine and are optimized to extract 14 doses per vial. For more information about the presentation of Moderna COVID-19 vaccine and its ancillary supply kit, see the Centers for Disease Control and Prevention (CDC) product information guide.

 Expiration date guidance

To find the expiration date for any vial:

  1. Go to the Moderna COVID-19 vaccine webpage.
  2. On the vial, find the lot number, printed on both the carton and vial.
  3. Enter the lot number in the website search field and press "Submit."
  4. Update the expiration date in WIR and other internal tracking system if applicable.

CDC's vaccine expiration date tracking tool can help you keep track of the expiration date by lot number.

  • Do not store on dry ice.
  • Vials can be stored refrigerated between 2° to 8°C (36° to 46°F) for up to 30 days prior to first use.
  • Unpunctured vials may be stored between 8° and 25°C (46° and 77°F) for up to 24 hours.
  • Do not refreeze once thawed.
  • Check the expiration date before preparing or administering vaccine. Never use expired vaccine or diluent. As additional stability data become available, the expiration dates for some products may change.

You can use the Moderna Temperature Excursion Tool to determine what should be done with vials that may have experienced a temperature excursion.

Clinical Resources

    Key webpages with clinical resources include:

     

    The following resources are also available on the above webpages:

    EUA Fact Sheets

    Storage and Handling

    Contacts
    Topic or Problem Contact
    • General Moderna questions
    • Health care provider questions (clinical)
    • Product quality or technical questions
    • Pregnancy registry

    Moderna's a 24/7 call center routes callers to one of four areas, based on their questions:

     Phone: 866-MODERNA (866-663-3762)

    Temperature excursions within the clinic or site  Phone: 866-MODERNA or 866-663-3762
     Email: excursions@modernatx.com
    Moderna vaccine had a temperature excursion during shipment

    Questions and concerns about vaccine viability issues (temperature excursions) during shipment must be reported on the same day as delivery.

     Phone: 833-272-6635 Monday – Friday, 7 a.m. - 7 p.m. CST
     Email: covidvaccinesupport@mckesson.com (only send email if after hours)

    Shipment issues or questions other than vaccine viability concerns  Email: dhscovidvaccinator@wi.gov
    Moderna ancillary kit has a problem McKesson Specialty
     Phone: 833-343-2703
     Email: covidvaccinesupport@mckesson.com
    A complex COVID-19 vaccine safety question about an individual patient residing in the U.S. not readily addressed by CDC guidance

    Healthcare personnel or health departments in the U.S. can request a consultation from
     The Clinical Immunization Safety Assessment COVIDvax project website
     Phone: 800-CDC-INFO (800-232-4636)

    Last Revised: July 27, 2021

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