HIV: Pre-Exposure Prophylaxis (PrEP) PrEP is a way to prevent HIV By taking one PrEP pill a day or receiving the long-acting injectable PrEP, a person using PrEP can reduce their risk of HIV transmission by up to 99%. What is PrEP? Is PrEP for me? Where do I get PrEP? How is PrEP paid for?