Substance Use: Risk Mitigation

Register now for the Wisconsin Substance Use Summit!

The Wisconsin Substance Use Summit features two dynamic keynote presentations and 48 engaging workshops focused on building healthy communities through substance use primary prevention, overdose prevention, intervention, treatment, and recovery services. Join us in Green Bay or virtually August 5-6, 2026, for this first-of-its-kind learning and networking event. CEHs are available. View the agenda and register today!

Improving outcomes for people who use drugs in Wisconsin

Providing comfort by clasping hands

Risk mitigation is an evidence-based public health approach to prevent overdoses and the spread of infectious diseases, like HIV and hepatitis C. Risk mitigation focuses on empowering people who use drugs to make safer choices to prevent negative health outcomes.

People mitigate risk every day to keep themselves safe. Wearing seatbelts and helmets, driving the speed limit, and exercising are everyday examples of risk mitigation.

Mitigating the risks associated with substance use is not enabling, condoning, or endorsing of drug use. Risk mitigation reduces the harms associated with substance use by providing life-saving overdose and infectious disease prevention and response services.

Benefits of risk mitigation programs

Risk mitigation programs keep communities safe by providing life-saving resources and education to prevent overdose and the spread of infectious diseases. Risk mitigation programs often distribute naloxone, a medicine that reverses overdoses, and infectious disease prevention supplies that keep people safe, healthy, and alive.

People accessing risk mitigation programs receive referrals to mental health services, substance use disorder treatment, and medical care, and are five times more likely to enter treatment for substance use disorder. Risk mitigation programs also help prevent the spread of infectious diseases by offering testing and treatment services. These programs also work with law enforcement to provide them with tools to safely respond to calls involving substance use.

What do risk mitigation programs look like?

Harm reduction programs provide life-saving overdose and infectious disease prevention services that improve health outcomes and connect people to resources. Harm reduction programs include a range of services:

Overdose education and naloxone distribution

Person looking at camera with words "I carry hope. I carry naloxone." over their shoulder

Naloxone is a medication that can reverse an overdose caused by an opioid drug like fentanyl, heroin, or prescription pain medications. Naloxone is widely available in Wisconsin.

Drug checking technology

Fentanyl test strips

Fentanyl and xylazines test strips indicate when either substance is present in a drug supply.

Public health mobile units

White panel van parked on the street

Wisconsin's Public Health Outreach and Response Team (PHORT) seeks to enhance and expand overdose and infectious disease prevention services in Wisconsin to reduce drug-related deaths and other harms.

Overdose Prevention Technical Assistance Centers (TACs)

Human resources concept drawing: people pushing interlocking puzzle pieces together

TACs provide support to newly formed harm reduction organizations who connect people who use drugs with resources.

Substance use statistics

Adult working with a futuristic concept of mobile data integration

DHS collects and analyzes data to identify where communities are struggling, help tailor our response, and show improvements in health and wellness.

Training

Safety First: Comprehensive, Harm-Reduction Based, Drug Intervention Curriculum for high school students

Resources

Glossary

 
Last revised July 17, 2026